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  • Writer's pictureRebel Scientist

How a 20-cent diabetes drug being used to reverse aging is giving people crappy results.

Metformin, known as a diabetes drug, has recently seen an uptick in off-label use for weight loss and anti-aging. The downside? It can have some severe gastrointestinal side effects, including diarrhea without warning.


But why are people suddenly so interested in Metformin as an anti-aging method? That would be because of the TAME Trial.


Conducted by the American Federation for Aging Research, the TAME (or Targeting Aging with Metformin) Trial is a series of nationwide, six-year clinical trials at 14 leading research institutions across the country that will engage over 3,000 individuals between the ages of 65-79.


However research has found that anywhere from one tenth to one third of patients may not be able to even tolerate use of the medication.



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