Metformin, known as a diabetes drug, has recently seen an uptick in off-label use for weight loss and anti-aging. The downside? It can have some severe gastrointestinal side effects, including diarrhea without warning.
But why are people suddenly so interested in Metformin as an anti-aging method? That would be because of the TAME Trial.
Conducted by the American Federation for Aging Research, the TAME (or Targeting Aging with Metformin) Trial is a series of nationwide, six-year clinical trials at 14 leading research institutions across the country that will engage over 3,000 individuals between the ages of 65-79.
However research has found that anywhere from one tenth to one third of patients may not be able to even tolerate use of the medication.